主要研究方向：炎症相关疾病的新靶点和新药发现研究研究背景：炎症是机体对损伤因子所发生的防御反应。然而，作为一柄双刃剑，过度或失控的炎症反应（天然免疫系统过度激活和炎症细胞因子过量表达）会导致组织损伤介导多种疾病的发生发展，是一种常见的病理过程，在多种疾病，如脓毒血症、肥胖与糖尿病及其并发症等代谢性疾病中起着重要的介导作用。因此，抑制过度炎症的药物有望应用于多种炎症相关性疾病的治疗。代谢和心血管疾病已成为人民健康的重要威胁，研发代谢相关疾病防治的新策略和新手段具有重要的医学价值与社会意义。慢性炎症是多种代谢性疾病的重要病理过程。在代谢性疾病的发生发展过程中，初始代谢异常的免疫应答导致机体和局部过度炎症的发生，过度炎症又导致病灶产生更多的炎性浸润放大炎症反应，进一步直接损伤组织细胞或代谢信号通路，它们正反馈式地促进代谢性疾病的发生发展。因此，抑制过度炎症反应可能成为多种代谢性疾病的治疗新策略。科学问题：虽然过度炎症与代谢性疾病的关系已有大量报道，但是，（1）新机制和新靶点：代谢紊乱的刺激物（高血糖、高血脂、高血压等）如何激活炎症反应？是否能从慢性炎症发生的过程和炎症调控的信号通路中找到防治代谢性疾病的新靶点？（2）抗炎新化合物：目前临床上的甾体或非甾体类抗炎药均靶向环氧化酶/前列腺素系统和炎性血管反应，并非靶向炎症因子过量表达的炎症信号通路，靶标单一，局限性强，无法用于慢性炎性疾病的治疗；而针对炎症因子及其受体的抗体类药物，其靶点在炎症发生的下游，对炎症因子的抑制种类单一，对大量多种炎症因子复合的炎症相关疾病和代谢性疾病治疗效果有限。因此，如何去寻找抑制过度炎症反应的新型抑制剂和候选新药？（3）候选新药：如何确证抑制过度炎症反应可以成为治疗代谢相关疾病的重要手段？结合新靶点和新化合物，能否寻找到基于抗炎机制治疗代谢性疾病和急性炎症疾病的候选新药？研究内容：我们瞄准过度炎症这一重要病理过程，以代谢性疾病和脓毒血症防治为目标导向，综合运用药理学、药物化学、分子生物学等多学科手段，主要在代谢性疾病中的慢性炎症发生机制和调控机制、抗炎新药发现和靶点确证、代谢性疾病的抗炎防治和新药发现等三个方面取得了系列研究成果，为代谢性疾病的抗炎治疗提供了新的干预策略和候选新药。（1） 代谢性疾病中的慢性炎症发生机制和调控机制：已完成的主要研究包括：首次发现饱和脂肪酸直接结合细胞膜上的MD2蛋白而激活炎症信号通路和心脏炎性损伤（Nat Comm, 2017）；阐明了血管紧张素通过促炎导致心肌损伤的新机制和靶点（Hypertension,2015等）；发现JNK2介导了糖尿病心肌病和肾病中的过度炎症发生过程（Diabetes, 2014；Kidney Int, 2017）；提出MD2、JNK2等可以成为治疗糖尿病并发症的有效靶点。目前正在开展研究包括：高血糖激活心肌细胞炎症反应的分子机制；动脉粥样硬化中炎症反应的发生机制；炎症发生的重要调控蛋白MyD88在代谢性心血管疾病中的作用和机制；寻找调控炎症的新型蛋白激酶及其在糖尿病心肾并发症中的作用和机制；寻找调控炎症的新型泛素化和去泛素化酶及其在急慢性炎症疾病中的作用与机制。（2） 抗炎新化合物发现和靶点确证：已完成的主要研究包括：基于天然先导和靶点结构进行合理药物设计，合成了千余个小分子化合物，并利用“LPS-巨噬细胞-炎症因子释放”体系，从中筛选发现了50个新型抗炎活性化合物（J Med Chem, 九篇）；通过药理机制研究，阐明了部分活性化合物抗炎的直接分子靶点，如MD2和JNK等（BJP, 六篇）。目前正在开展研究包括：含氮杂环类化合物中设计和寻找新型抗炎化合物；以天然产物为先导物的药物化学结构优化与抗炎新化合物设计发现；天然产物中的抗炎化合物的分子靶点和化学生物学研究；靶向MD2、MyD88、DCLK1、PLCy等蛋白的新型抗炎化合物设计合成与评估；新型抗炎短肽的设计与发现；新型抗炎药物设计和靶点分子动力学模拟研究。（3）代谢性疾病的抗炎防治和新药发现：  将自己发现的多个抗炎活性化合物用于疾病治疗，阐明了它们的药效作用和药理机制，并对多个新化合物进行了成药性评价。其中，靶向MD2的新化合物X22作为脓毒血症的1.1类候选新药，靶向JNK2的新化合物C66作为糖尿病肾病的1.1类候选新药，都已进入临床前研发阶段，并获得国家新药创制重大专项支持。目前正在开展其他几个候选新化合物的成药性评价和新药临床前研究，它们基于抗炎靶点和机制有望治疗糖尿病肾病、高血压心衰和结肠炎。其它研究方向：抗肿瘤药物化学与抗肿瘤药理机制研究1 抗肿瘤药物化学研究1.1 以天然产物为先导物的药物设计、合成、抗肿瘤构效关系研究1.2 靶向IKK、EGFR、FGFRs等靶点的抗肿瘤药物设计、合成和构效关系研究1.3 新型抗肿瘤药物设计和靶点分子动力学模拟研究2 抗肿瘤药理机制研究2.1新发现的抗肿瘤活性化合物的药理机制和药效研究2.2 天然产物及其类似物通过激活ROS诱导肿瘤凋亡的作用机制研究2.3旁路激活与肿瘤耐药的分子机制研究2.4 端粒与G4在炎癌转化的作用机制研究2.5 肿瘤中lncRNA和miRNA的作用和机制研究

2026年89. Haibin Wu#*, Jixiang Zhang#, Xinqing Huang#, Bo Zhang#, Yuting Xie, Qingyu Li, Li Yang, Weiqi Wu, Ziying Zheng, Ziyan Huang, Fanru Gao, Zhongqing Cai, Jiahe Chen, Guohuan Zeng, Daishun Ling*, Guang Liang*, Qian Chen*. A Gas-Liquid Biphasic Nanocleaner for Breaking the Self-Amplified Vicious Cycle of Barrier Disruption-Inflammation in Inflammatory Bowel Disease. Journal of Nanobiotechnology, 2026, Accepted (一区TOP，IF=12.6)88. Haibin Wu#*, Ziying Zheng#, Lenan Xu#, Ziyan Huang, Yi Qiu, Shuhan Shi, Jixiang Zhang, Ke Duan, Fengling Song, Honglei Zhang, Qingyu Li, Xinqing Huang, Yawen Zhang, Lina Yin, Qian Chen*, Daishun Ling*, Guang Liang*. Self-traceable, Self-protective, and Self-sufficient Combinational Catalytic Therapy of Inflammatory Bowel Disease by a Smart Nanozyme-DNAzyme Platform, Materials Today, 2026, Accepted. (一区，IF=22)87. Xia Zhao#*, Yingzhou Li#, Ziyao Meng, Xiaoxia Xu, Linjie Chen, Qin Yu, Ruya Wang, Yiyu Ren, Fan Chen, Qi Ai, Yu Deng, Houming Yu, Jurui Wei, Guang Liang* . The Role and Therapeutic Potential of DNA Glycosylases in Alzheimer's Disease. Ageing Research Reviews, 2026, 118: 103129. (一区，IF=14.51)[87-2026.pdf]86. Xue Han*, Zhuqi Huang*, Guoxuan Liu, Yanan Liu, Weiqi Li, Jianing Zheng, Jie Tong, Mingyang He, Yurou Wu, Ze Li, Wu Luo, Qiaojuan Shi, Huazhong Ying#, Guang Liang#. VCPIP1 Drives Diabetic Cardiomyopathy by Deubiquitinating AMPKγ1 and Preventing AMPKα-γ Subunit Assembly in Cardiomyocytes. Signal Transduction and Targeted Therapy, 2026, 11:185. （一区，IF=52.7）[86-2026.pdf]85. Yawen Zhang, Xuanyu Tang, Yijing Ma, Yi Qiu, Xiaoting Wu, Yue Wu, Lulu Zeng, Lingfeng Chen, Haibin Wu, Yanyan Zheng, Jing Xie*, Guang Liang*, Lina Yin*. Microneedle-delivered ROS-adaptive asiatic acid nanoparticles promote scarless repair via remodeling the pathological microenvironment. J Nanobiotechnology. 2026,24(1):171. （一区，IF=12.6）[85-2026.pdf]84. Shiju Ye#, Yanbo Zhao#, Hanxiao Tu#, Xue Han, Tong Liu, Yingchao Gong, Jiangting Lu, Tingting Jin, Wu Luo, Xuefeng Qu, Dongwu Lai, Guosheng Fu*, Guang Liang*. Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling, Nature Communications, 2026, Accepted. (一区，IF=15.7）83. Qian Zhou*, Xuejin Jin*, Miao Yuan, Huanyan Tao, Shenjie Bao, Jingnan Zhang, Zheng Xu, Nipon Chattipakorn, Yi Wang, Hong Zhu*, Guang Liang*. Lycorine improves inflammatory imbalance in diabetic cardiomyopathy by targeting ILF3, Phytomedicine, 2026, Accepted. (一区，IF=8.3)82. Xia Zhao, Fan Chen, Li Xiong, Xiaoxia Xu, Ziyao Meng, Yu Deng, Qi Ai, Luyao Li, Qin Yu, Linjie Chen, Ruya Wang, Yiyu Ren, Wenhua Zheng, Jurui Wei, Houming Yu, Guang Liang*. OTUD6A Drives Dopaminergic Neuronal Degeneration of Parkinson's Disease through Deubiquitinating ACTG1 in Neuronal Cells. Acta Pharmaceutica Sinica B. 2026,16(2), 820–835.（一区；IF=14.7)[82-2026.pdf]2025年81. Yarong Wu#, Yu Deng#, Qi Ai#, Yingzhou Li, Feiya Qi, Muzaffar Hammad, Ziyao Meng, Xiaoxia Xu, Jurui Wei, Houming Yu, Guang Liang*, Xia Zhao*. Deubiquitinating enzymes in parkinson's disease: molecular mechanisms and therapeutic potential. Mol Med. 2025,31(1):329.（二区，IF=6.4）[81-2025.pdf]80. Qingxia Zhao, Haojie Ge, Huimin Jin, Lingfeng Chen, Guang Liang*, Patrick J. Walsh*, and Jie Li*. Base-Promoted Tandem Synthesis of Indolo[1,2 b]isoquinolines from 2 Alkynylaniline and Nitroarenes. J Org Chem. 2025,90(33):11852-11859. (二区,IF=3.6)[80-2025.pdf]79. Xuejin Jin#, Lingkun Wang#, Miao Yuan, Huanyan Tao, Huiyan Zha, Zheng Xu, Guang Liang, Xiangwei Xu*, Qian Zhou*. Taxifolin attenuates cisplatin-induced acute kidney injury by promoting fatty acid oxidation. J Biochem Mol Toxicol. 2025,39(10):e70559. (三区，IF=3.2).[79-2025.pdf]78. Mincong Huang*#, Mengyao Lan#, Xin Liu, Cailu Lin, Lulu Zeng, Ying Li, Feng Li, Xiaotong Dou, Yan Zhao, Yuan Shi, Xiangwei Xu*, Jinfeng Sun*, Guang Liang*. Isolinderalactone regulates macrophage polarization and efferocytosis by activating the LXRα pathway against ulcerative colitis. Chin Med. 2025,20(1):152.（二区，IF=5.7)[78-2025.pdf]77. Sha Shi, Chengkai Zhu, Jiaqi Xu, Qi Sui, Shanhao Zhu, Jingnan Zhang, Peng Chen*, Guang Liang*, Yi Zhang*. Gigantol: a principal bioactive constituent of Dendrobium species-multi-target mechanisms, network pharmacology, and therapeutic perspectives. J Ethnopharmacol. 2026,355(Pt A):120595. (一区，5.4）[77-2025.pdf]76. Zheng Xu#, Yihan Shen#, Xiaoting Luo, Jingru Wang, Qian Zhou, Xue Han, Juan Ren, Lihong Wang, Guang Liang*. Angiotensin II-induced phosphorylation of CHK1 at serine-280 drives cardiac remodelling by direct phosphorylation of JAK1, thus activating JAK1-STAT signalling in murine cardiomyocytes. Br J Pharmacol. 2025,182(24):6120-6135. （二区，IF=7.7）[76-2025.pdf]75. Xia Zhao#*, Jinfeng Sun#, Fan Chen, Hao Tang, Yuqing Zeng, Luyao Li, Qin Yu, Linjie Chen, Muzaffar Hammad, Xiaoxia Xu, Ziyao Meng, Wei Wang*, Guang Liang*. YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2. Clin Transl Med. 2025,15(7):e70420. (二区, IF=6.8)[75-2025.pdf]74. Li Xiong#, Qin Yu#, Linjie Chen#, Yu Deng, Qi Ai, Xiaoxia Xu, Ziyao Meng, Fan Chen, Xia Zhao*, Jurui Wei*, Houming Yu*. Curcumin analogue C66 Ameliorates the Pathology of Alzheimer's Disease through suppression of JNK signaling pathway. Int Immunopharmacol. 2025,162:115156. (二区，IF=4.8)[74-2025.pdf]73. Xue Han, Ruyi Zheng, Jiajia Zhang, Yanan Liu, Ze Li, Guoxuan Liu, Jianing Zheng, Weiqi Li, Zijun Liang, Mengyang Wang, Jie Yu, Qiaojuan Shi#, Huazhong Ying#, Guang Liang#. Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 to inhibit AMPK activity and induce mitochondrial dysfunction. Nat Commun. 2025,16(1):6668. (一区，IF=15.7）[73-2025.pdf]72. Lulu Zheng#, Jiaqi Cao#, Lin Ma#, Shiyan Chen#, Xiansheng Cao, Ruixiang Luo, Yuhan Wang, Di Ke*, Ping Huang*, Guang Liang*, Lingfeng Chen*. LC-MF-4, a Novel FGFR3 Degrader for Therapeutic Intervention in FGFR3-Altered Cancers. J Med Chem. 2025,68(13):13858-13871. (一区，IF=6.8）[72-2025.pdf]71. Runjie Fan, Rongxing Zhu, Xiangxiu Cao, Shuhui Ye, Fengyi Gao, Yue Wu, Wanxin Yao, Guang Liang*, Yanmei Zhang*. PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140. Mol Med. 2025,31(1):216. (二区，IF=6)[71-2025.pdf]70. Qi Sui, Chengkai Zhu, Sha Shi, Jiaqi Xu, Jingnan Zhang, Ao Wang, Peng Chen*, Guang Liang*, Yi Zhang*. Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis. J Ethnopharmacol. 2025,349:119868. (一区，IF=4.8）[70-2025.pdf]69. Sha Shi, Meiling Zhang, Chengkai Zhu, Shanhao Zhu, Jie Yu, Qi Sui, Jiaqi Xu, Juan Ren, Jingnan Zhang*, Peng Chen*, Yi Zhang*. Tamoxifen regulates ferroptosis of hepatocytes by targeting SLC1A5 to activate hepatic stellate cells and liver fibrosis. Chem Biol Interact. 2025,418:111586. (一区，IF=4.7）[69-2025.pdf]68. Lei Zheng#, Yuhan Wang#, Zheng Jiang#, Shiyan Chen, Xiansheng Cao, Xiaohao Huang, Ruixiang Luo, Lulu Zheng, Qin Li, Linglan Tu, Jie Li, Guang Liang*, Lingfeng Chen*. Discovery of LC-SF-14, a selective dual inhibitor of SHP2 and FGFR for the treatment of FGFR2-driven gastric cancer. Eur J Med Chem. 2025,294:117745. (一区, IF=6.0)[68-2025.pdf]67. Mengyang Wang#, Xue Han#, Qinyan Wang#, Tianxiang Yu, Wu Luo, Shiju Ye, Xiaochen Guo, Zheng Xu, Zhuqi Huang, Julian Min, Ping Huang, Yi Wang, Guang Liang*. Checkpoint kinase Wee1 activation drives inflammation and hypertrophy through the protein kinase B/phosphoinositide 3-kinases–nuclear factor κB pathway in cardiomyocytes. Eur Heart J. 2025,ehaf349.（一区，IF=38.1）[67-2025.pdf]66. Lingfeng Chen*#, Di Ke#, Zheng Jiang#, Ruixiang Luo, Jie Li, Lulu Zheng, Guang Liang*. Screening of tyrosine phosphatase SHP2 (PTPN11) inhibitors from natural products with therapeutic potential for receptor tyrosine kinase-driven cancer. Journal of Pharmaceutical Analysis, 2026, 16(2):101335 (一区TOP，IF=8.9)[66-2025.pdf]65. Lingyu She#, Luyao Li#, Hao Tang#, Qin Yu, Fengyi Gao, Yuqing Zeng, Linjie Chen, Li Xiong, Liwei Li, Fan Chen, Jinfeng Sun, Wenhua Zheng, Xia Zhao*, Guang Liang*. OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ. Acta Pharmacol Sin. 2025,46(10):2608-2621. (一区，IF=6.9)[65-2025.pdf]64. Xuejin Jin, Miao Yuan, Lingkun Wang, Huiyan Zha, Zhiwei Zheng, Zheng Xu, Jing Shi, Guang Liang, Qian Zhou. Curcumol Ameliorates Cisplatin-induced Nephrotoxicity by Targeting TAK1 and Inhibiting MAPK and NF-κB Pathways. Phytomedicine. 2025,141:156752. (一区， IF=6.7)[64-2025.pdf]63. Haibin Wu, Shuhan Shi, Lenan Xu, Ziying Zheng, Ziyan Huang, Yi Qiu, Jixiang Zhang, Keyun Yang, Yuting Xie, Cheng Xu, Tianyang Xu, Guohuan Zeng, Lingfeng Chen, Mincong Huang, Qian Chen*, Daishun Ling*, Guang Liang*, Nanozyme engineered ROS-tolerant cysteine active-site for upstream deubiquitylation therapy of inflammatory bowel disease. Nano Today. 2025,62:102735. (一区，IF=13.2）[63-2025.pdf]62. Zhuqi Huang#, Sirui Shen#, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang*, Guang Liang*. Macrophage WEE1 Directly Binds to and Phosphorylates NF-κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis, Adv Sci (Weinh). 2025,12(26):e2503192. (一区，IF=14.3)[62-2025.pdf]61. Bozhi Ye#, Diyun Xu#, Lingfeng Zhong#, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang*, Guang Liang*. USP25 improves myocardial ischemia-reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes, Clin Transl Med. 2025,15(2):e70243. (一区，IF=7.9）[61-2025.pdf]60. Xue Han#, Qiaojuan Shi#, Yu Tu, Jiajia Zhang, Mengyang Wang, Weiqi Li, Yanan Liu, Ruyi Zheng, Jiajia Wei, Shiju Ye, Yanmei Zhang, Bozhi Ye, Yi Wang, Huazhong Ying*, Guang Liang*. Cardiomyocyte PRL2 Promotes Cardiac Hypertrophy via Directly Dephosphorylating AMPKα2. Circ Res. 2025,136(7):645-663. (一区，IF=16.5)[60-2025.pdf]59. Hao Tang#, Luyao Li#, Qin Yu, Linjie Chen, Xiaoxia Xu, Ziyao Meng, Yuqing Zeng, Fan Chen, Hammad Muzaffar, Wei Wang*, Xia Zhao* and Guang Liang*. Sclareol improves the pathology of Alzheimer's disease by inhibiting microglial inflammation via interacting with CDK9. Phytomedicine. 2025,139:156504.  (一区，IF=6.7)[59-2025.pdf]58. Yaoxiang Lin, Lulu Zheng, Ying Xu, Xinyan Wang, Jie Li, Lei Zheng*, Guang Liang* and Lingfeng Chen*. Interleukin‑1 Receptor-Associated Kinase 4 (IRAK4) Degraders for Treating Inflammatory Diseases: Advances and Prospects. J Med Chem. 2025,68(2):902-914. (一区，IF=6.9)[58-2025.pdf]57. Xin Liu#, Yi Fang#, Mincong Huang, Shiliang Tu, Mengyao Lan, Boan Zheng, Hang Yuan, Peng Yu, Yongqiang Zhou, Wu Luo, Guorong Chen, Zhe Shen, Yi Wang, Guang Liang*. Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages. Acta Pharm Sin B. 2025,15(2):1039-1055. (一区, IF=14.5)[57-2025.pdf]56. Jinfeng Sun#, Fan Chen#, Lingyu She, Yuqing Zeng, Hao Tang, Bozhi Ye, Wenhua Zheng, Li Xiong, Liwei Li, Luyao Li, Qin Yu, Linjie Chen, Wei Wang, Guang Liang*, Xia Zhao*. YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease. Acta Pharm Sin B. 2025,15(1):331-348. (一区, IF=14.5)[56-2025.pdf]2024年55. Huimin Jin#, Fan Zhou#, Zhenhua Xiang, Lingfeng Chen, Guang Liang*, Patrick J. Walsh* and Jie Li*. Base-Promoted Synthesis of N-H Free Pyrroles via net [3+2]-Cycloaddition. Adv. Synth. Catal. 2024,366:942–947(二区，IF=4.4)[55-2024.pdf]54. Sujuan Shuai#, Jianyou Mao#, Fan Zhou#, Qifeng Yan, Lingfeng Chen, Jie Li*, Patrick J. Walsh* and Guang Liang*. Base-Promoted Synthesis of Isoquinolines through a Tandem Reaction of 2‑Methyl-arylaldehydes and Nitriles. J Org Chem. 2024,89(10):6793-6797. (二区，IF=3.3)[54-2024.pdf]53. Wanxin Yao#, Chen Liu#, Ningyin Zhang, Yanmei Zhang* and YONG QIAN*. Atractyloside inhibits gefitinib‑resistant non‑small‑cell lung cancer cell proliferation. Oncol Lett. 2024,28(4):466. (四区，IF=2.5)[53-2024.pdf]52. Liwei Li#; Jinfeng Sun#; Fan Chen; Li Xiong; Lingyu She; Hao Tang; Yuqing Zeng; Luyao Li; Wei Wang; Xia Zhao*; Guang Liang*. Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade. Chin Med. 2024,19(1):163. (二区，IF=5.3)[52-2024.pdf]51. Mengyao Lan, Cailu Lin, Lulu Zeng, Shijie Hu, Yuan Shi, Yan Zhao, Xin Liu, Jinfeng Sun, Guang Liang*, Mincong Huang*. Linderanine C regulates macrophage polarization by inhibiting the MAPK signaling pathway against ulcerative colitis. Biomed Pharmacother. 2024,178:117239.（一区，IF=6.9）[51-2024.pdf]50. Yuqing Zeng#, Li Xiong#, Hao Tang, Linjie Chen, Qin Yu, Liwei Li, Fan Chen, Luyao Li, Yanyan Zheng, Jinfeng Sun, Lingyu She, Wei Wang*, Guang Liang* and Xia Zhao*. Norboldine improves cognitive impairment and pathological features in Alzheimer's Disease by activating AMPK/GSK3β/Nrf2 signaling pathway. J Ethnopharmacol. 2024,333:118498. (一区，5.4)[50-2024.pdf]49. Xiaobo Li, Xinyi Huang, Yunxi Zhao, Zhiwei Zheng, Mi Guo, Zhicao Chen, Pan Chen, Xiang Li, Jing Liao, Miao Jiang, Won-Jea Cho, Young-Chang Cho, Ruifeng Zeng*, Qidong Tang*, Guang Liang*. Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis. Eur J Med Chem. 2024,272:116487. （一区，IF=6.7）[49-2024.pdf]48. Lintao Wang, Wu Luo, Suya Zhang, Junsheng Zhang, Lu He, Yifan Shi, Li Gao, Baochuan Wu, Xiaoyan Nie, Chenghong Hu, Xue Han, Chaoyong He*, Biao Xu*, Guang Liang*. Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signaling pathway. Cardiovasc Res. 2024,120(12):1385-1399.（一区，IF=10.8）[48-2024.pdf]47. Lingfeng Chen*#, Ruixiang Luo#, Lin Ma#, Ying Xu#, Jiaqi Cao, Zheng Jiang, Lei Zheng, Yawen Zhang, Lina Yin, Jie Yu, Xiaochun Zheng, Lulu Zheng, Ping Huang, Guang Liang*. Discovery of LC-MI-3: a potent and orally bioavailable degrader of interleukin-1 receptor associated kinase 4 for the treatment of inflammatory diseases. J Med Chem. 2024,67(10):8060-8076. (一区，IF=7.3)[47-2024.pdf]46. Xiaoyu Sun, Tong Wu, Zhan Yang, Shuhong Chen, Zheyu Zhao, Chaoming Hu, Shengzhuang Wu, Jiayu Wu, Yixin Mao, Jiefan Liu, Chen Guo, Gang Cao, Xiangwei Xu*, Shengbin Huang*, Guang Liang*. Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis. Gene. 2024,918:148476.（三区，IF=3.5)[46-2024.pdf]45. Jiamin Wang#, Sujuan Shuai#, Lishe Gan#, Yongxin Luo, Huimin Jin, Lingfeng Chen, Dong Zou, Guang Liang*, Patrick J. Walsh* and Jie Li*. Cation-controlled chemoselective synthesis ofN-aroylureas and imides via amidation of N-Bocarylamides. Organic Chemistry Frontiers. 2023,10:2061-2069.(一区，IF=5.4）[45-2024.pdf]44. Ao Wang, Yi Zhang, Xinting Lv, Guang Liang*. Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases. Acta Pharm Sin B. 2024,14(8):3295-3311. (一区，IF=14.5）[44-2024.pdf]43. Binhao Cai#, Ying Xu#, Ruixiang Luo#, Kongqin Lu, Yuhan Wang, Lei Zheng, Yawen Zhang, Lina Yin, Linglan Tu, Wu Luo, Lulu Zheng, Fengzhi Zhang, Xinting Lv, Qidong Tang*, Guang Liang*, Lingfeng Chen*. Discovery of a doublecortin-like kinase 1 inhibitor to prevent inflammatory responses in acute lung injury. Bioorg Chem. 2024,145:107215. (一区，IF=5.1)[43-2024.pdf]42. Xue Han#, Jiajia Wei#, Ruyi Zheng, Yu Tu, Mengyang Wang, Lingfeng Chen, Zheng Xu, Lei Zheng, Chao Zheng, Qiaojuan Shi*，Huazhong Ying*, Guang Liang*. Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB-Dependent Inflammation. Diabetes. 2024,73(5):780-796. (一区，IF=7.7)[42-2024.pdf]41. Xiaoyu Sun, Shuhong Chen, Ying Zhao, Tong Wu, Zheyu Zhao, Wu Luo, Jibo Han, Zimin Fang, Bozhi Ye, Gang Cao, Shengbin Huang*, Guang Liang*. OTUD6A in tubular epithelial cells mediates Angiotensin II-induced kidney injury by targeting STAT3. Am J Physiol Cell Physiol. 2024,326(2):C400-C413. (二区，IF=5.5)[41-2024.pdf]40. Yue Wu#, Yawen Zhang#, Xuanyu Tang, Shuhui Ye, Jingjing Shao, Linglan Tu, junzhi Pan, Lingfeng Chen*, Guang Liang*, and Lina Yin*. Synergistic anti-oxidant and anti-inflammatory effects of Ceria/Resatorvid co-decorated nanoparticles for acute lung injury therapy. J Nanobiotechnology. 2023,21(1):502. （一区，IF=10.2）[40-2024.pdf]39. Li Xiong#, Lingyu She#, Jinfeng Sun1, Xiangwei Xu, Liwei Li, Yuqing Zeng, Hao Tang, Guang Liang*, Wei Wang* and Xia Zhao* . Isolinderalactone Ameliorates the Pathology of Alzheimer's Disease by Inhibiting the JNK Signaling Pathway. J Nat Prod. 2023,86(12):2718-2729.（二区，IF=5.1）[39-2024.pdf]38. Mengyang Wang#, Tianxiang Yu#, Qinyan Wang, Xue Han, Xiang Hu, Shiju Ye, Xiaohong Long, Yi Wang, Hong Zhu, Wu Luo*, Guang Liang*. OTUD1 Promotes Hypertensive Kidney Fibrosis and Injury by Deubiquitinating CDK9 in Renal Epithelial Cells. Acta Pharmacol Sin. 2024,45(4):765-776. (一区，IF=8.2)[38-2024.pdf]37. Lingyu She#, Hao Tang#, Yuqing Zeng#, Li Xiong, Jinfeng Sun, Liwei Li, Fan Chen, Juan Ren, Jing Zhang, Wei Wang*, Xia Zhao*, Guang Liang*. Ginsenoside RK3 promotes neurogenesis in Alzheimer's disease through activation of the CREB/BDNF pathway. J Ethnopharmacol. 2024,321:117462. (一区，IF=5.4)[37-2024.pdf]36. Jiajia Zhang#, Yu Tu#, Jiajia Wei, Ruyi Zheng, Ji Shao, Qinhua Chen, Guang Liang, Huazhong Ying*, Xue Han*, Qiaojuan Shi*. Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway. Biochim Biophys Acta Mol Basis Dis. 2024,1870(1):166911. (一区, IF=6.2)[36-2024.pdf]2023年35. Jinfeng Sun#, Liwei Li#, Li Xiong, Fan Chen, Lingyu She, Hao Tang, Yuqing Zeng, Ying Duan, Yao Lu, Wei Wang, Gao Li*, Xia Zhao*, Guang Liang*. Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway. Biomed Pharmacother. 2023,169:115909. （一区，IF=7.5）[35-2023.pdf]34. Tianxiang Yu, Jiachen Xu, Qinyan Wang, Xue Han, Yu Tu, Yi Wang, Wu Luo, Mengyang Wang*, Guang Liang*. 20(S)-ginsenoside Rh2 inhibits Angiotensin-2 mediated cardiac remodeling and inflammation asscociated with suppression of the JNK/AP-1 pathway. Biomed Pharmacother. 2023,169:115880.（一区，IF=7.5）[34-2023.pdf]33. Huimin Jin, Fan Zhou, Zhenhua Xiang, Lingfeng Chen, Guang Liang*, Patrick J. Walsh*, Jie Li*. Base-Promoted Synthesis of N-H Free Pyrroles via net [3+2]-Cycloaddition. Adv. Synth. Catal, 2023,365:1-6. （二区，IF=5.4）[33-2023.pdf]32. Lingyu She, Jinfeng Sun, Li Xiong, Ankang Li, Liwei Li, Haibin Wu, Juan Ren, Wei Wang4*, Guang Liang* and  Xia Zhao*. Ginsenoside RK1 improves cognitive impairments and pathological changes in Alzheimer's disease via stimulation of the AMPK/Nrf2 signaling pathway. Phytomedicine. 2024,122:155168. (一区，IF=7.9）[32-2023.pdf]31. Minxiu Wang, Qianhui Zhang, Shuaijie Lou, Leiming Jin, Gaojun Wu, Wenqi Wu, Qidong Tang, Yi Wang, Xiaohong Long, Ping Huang, Wu Luo, Guang Liang*. Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice. Biomed Pharmacother. 2023,168:115660.（一区，IF=7.5)[31-2023.pdf]30. Yawen Zhang, Yue Wu, Yuping Yan, Yijing Ma, Linglan Tu, Jingjing Shao, Xuanyu Tang, Lingfeng Chen, Guang Liang*, Lina Yin*. Dual-Targeted Nanoparticle-In-Microparticle System for Ulcerative Colitis Therapy. Adv Healthc Mater. 2023,12(31):e2301518. (一区, IF=10.0)[30-2023.pdf]29. Pan Chen, Jun Yang, Ying Zhou, Xiaobo Li, Yu Zou, Zhiwei Zheng, Mi Guo, Zhichao Chen, Won-Jea Cho, Nipon Chattipakorn, Wenqi Wu*, Qidong Tang*, Guang Liang*. Design, synthesis, and bioactivity evaluation of novel amide/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative colitis. Eur J Med Chem. 2023,259:115706. (一区，IF=6.7）[29-2023.pdf]28. Bin Yang#, Yunjie Zhao#, Wu Luo#, Weiwei Zhu, Leiming Jin, Minxiu Wang, Lin Ye, Yi Wang*, Guang Liang*. Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway. Cell Death Dis. 2023,14(7):419.（二区，IF=9.0）[28-2023.pdf]27. Xia Zhao#, Jinfeng Sun#, Li Xiong, Lingyu She, Liwei Li, Hao Tang, Yuqing Zeng, Fan Chen, Xue Han, Shiju Ye, Wei Wang, Xu Wang, Guang Liang*. β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease. Int J Biol Sci. 2023,19(10):3249-3265.（二区，IF=10.75）[27-2023.pdf]26. Haibin Wu#, Min Wei#, Shen Hu#, Pu Cheng, Shuhan Shi, Fan Xia, Lenan Xu, Lina Yin, Guang Liang*，Fangyuan Li*, Daishun Ling*. A Photomodulable Bacteriophage-Spike Nanozyme Enables Dually Enhanced Biofilm Penetration and Bacterial Capture for Photothermal-Boosted Catalytic Therapy of MRSA Infections. Adv Sci (Weinh). 2023,10(24):e2301694. （一区，IF=17.521）[26-2023.pdf]25. Lingfeng Chen#, Lili Fu#, Jingchuan Sun#, Zhiqiang Huang#, Mingzhen Fang#, Allen Zinkle, Xin Liu, Junliang Lu, Zixiang Pan, Yang Wang, Guang Liang, Xiaokun Li*, Gaozhi Chen*, Moosa Mohammadi*. Structural Basis for FGF hormone Signaling. Nature. 2023,618(7966):862-870. (一区，IF=69.50）[25-2023.pdf]24. Tianxiang Yu#, Xiangwei Xu#, Jiajia Wei, Jiachen Xu, Wu Luo, Ankang Li, Guang Liang*, Mengyang Wang*. Ginsenoside Rg5 alleviates Ang II–induced cardiac inflammation and remodeling by inhibiting the JNK/AP-1 pathway. Int Immunopharmacol. 2023,120:110408.  (二区，IF=5.71）[24-2023.pdf]23. Lin Ma#, Yingying Li#, Ruixiang Luo#, Yuhan Wang, Jiaqi Cao, Weitao Fu, Bolan Qian, Lei Zheng, Longguang Tang, Xinting Lv, Lulu Zheng*, Guang Liang*, Lingfeng Chen*. Discovery of a selective and orally bioavailable FGFR2 degrader for treating gastric cancer. J Med Chem. 2023,66(11):7438-7453. (一区，IF=8.04）[23-2023.pdf]22. Mengyang Wang, Xue Han, Tianxiang Yu, Minxiu Wang, Wu Luo, Chunpeng Zou, Xiuyun Li, Gao Li, Gaojun Wu, Yi Wang*, Guang Liang*. OTUD1 Promotes Pathological Cardiac Remodeling and Heart Failure by Targeting STAT3 in Cardiomyocytes. Theranostics. 2023,13(7):2263-2280. (一区，IF=11.6)[22-2023.pdf]21.Ruixiang Luo#, Weitao Fu#, Jingjing Shao#, Lin Ma#, Sujuan Shuai, Ying Xu, Zheng Jiang, Zenghui Ye, Lulu Zheng, Lei Zheng, Jie Yu, Yawen Zhang, Lina Yin, Linglan Tu, Xinting Lv, Jie Li*, Guang Liang*, Lingfeng Chen*. Discovery of a potent and selective allosteric inhibitor targeting the SHP2 tunnel site for RTK-driven cancer treatment. Eur J Med Chem. 2023,253:115305. (一区, IF =7.08)[21-2023.pdf]20.Jiahao Chen, Wu Luo, Chenghong Hu, Miao Ren, Haowen Xu, Xiangwei Xu, Weifeng Li, Yue Chen, Jingjing Shao, Zhongxiang Xiao, Xinting Lv*, Guang Liang*. Tanshinone IIA analogue 15a inhibits NLRP3-mediated inflammation by activating mitophagy in macrophages to alleviate acute tubular necrosis. Int Immunopharmacol. 2023,118:110065. (二区，IF=5.71）[20-2023.pdf]19.Lenan Xu, Meiling Zhang, Junzhi Pan, Xiangwei Xu, Yawen Zhang, Xue Han, Lina Yin, Lingfeng Chen, Juan Ren, Jie Yu, Yanmei Zhang, Guang Liang*, Yi Zhang*. Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway. Front Pharmacol. 2023,14:1135366. (二区，IF=5.98）[19-2023.pdf]18.Bowen Zuo#, Wanxin Yao, Mengdie Fang, Juan Ren, Linglan Tu, Runjie Fan, Yanmei Zhang*. Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation. Cancer Sci. 2023,114(5):1972-1985. (二区，IF=6.518)[18-2023.pdf]17.Hao Xu#, Mengdie Fang, Bowen Zuo, Wanxin Yao, Juan Ren, Yanmei Zhang*. circAR-E2E4-miR-665-STAT3 axis is a potential regulatory network in triple-negative breast cancer. Heliyon. 2022,9(1):e12654. (4区,IF=3.776)[17-2023.pdf]16.Lili Zhong#, Yuankai Qin#, Mei Liu#, Jinfeng Sun, Hao Tang, Yuqing Zeng, Jing Zhang, Wei Wang, Guang Liang*, Xia Zhao*. Magnoflorine improves cognitive deficits and pathology of Alzheimer's disease via inhibiting of JNK signaling pathway. Phytomedicine. 2023,112:154714. (一区，IF=6.66)[16-2023.pdf]15.Yi Zhang#, Binhao Cai#, Yingying Li#, Ying Xu, Yuhan Wang, Lulu Zheng, Xiaochun Zheng, Lina Yin, Gaozhi Chen, Yunxiang Wang*, Guang Liang*, Lingfeng Chen*. Identification of Linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis. Front Pharmacol. 2023,14:1098463. (二区, IF=5.98)[15-2023.pdf]14.Shiju Ye#, Huang He#, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Weijian Huang, Yi Wang, Xiaohong Long, Guosheng Fu*, Guang Liang*. Dectin-1 acts as a non-classical receptor of Ang II to induce cardiac remodeling. Circ Res. 2023,132(6):707-722. (一区，IF=23.2）[14-2023.pdf]13. Shuhui Ye#, Bowen Zuo#, Lenan Xu, Yue Wu, Ruixiang Luo, Lin Ma, Wanxin Yao, Lingfeng Chen, Guang Liang*, Yanmei Zhang*. Inhibition of SHP2 by the Small Molecule Drug SHP099 Prevents Lipopolysaccharide-Induced Acute Lung Injury in Mice. Inflammation. 2023,46(3):975-986.（二区，IF=4.657) [13-2023.pdf]12.Lingyu She#, Li Xiong#, Liwei Li, Jing Zhang, Jinfeng Sun, Haibin Wu, Juan Ren, Wei Wang*, Xia Zhao*, Guang Liang*. Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway. Biomed Pharmacother. 2023,158:114192. (一区，IF=7.42) [12-2023.pdf]  2022年11.Hao Xu#, Mengdie Fang, Chao Li, Bowen Zuo, Juan Ren, Yanmei Zhang*. BORIS-mediated generation of circular RNAs induces inflammation. Transl Oncol. 2022,18:101363. (3区,IF=4.803)[11-2022.pdf]10.Jie Li, Huan Wang, Huimin Jin, Zhenhua Xiang, Lingfeng Chen, Patrick Walsh, Guang Liang*. Base-promoted tandem synthesis of 3,4-dihydroisoquinolones. Org Lett. 2022,24(44):8125-8129.（一区，IF=6.07）[10-2022.pdf] 9.Minxiu Wang, Leiming Jin, Qianhui Zhang, Weiwei Zhu, Hanghui He, Shuaijie Lou, Wu Luo, Xue Han, Guang Liang*. Curcumin analog JM-2 alleviates diabetic cardiomyopathy inflammation and remodeling by inhibiting the NF-κB pathway. Biomed Pharmacother. 2022,154:113590. (二区，IF=7.42）[9-2022.pdf]8.Yanmei Zhang*,#, Mengdie Fang#, Shouye Li, Hao Xu, Juan Ren, Linglan Tu, Bowen Zuo, Wanxin Yao, Guang Liang*. BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer. Mol Cancer. 2022,21(1):158. (一区，IF=41）[8-2022.pdf]7.Jie Li, Dong Zou, Bo Wang, Ayşegül İşcan, Huimin Jin, Lingfeng Chen, Fan Zhou, Patrick J. Walsh*, Guang Liang*. Arylations with nitroarenes for one-pot syntheses of triaryl-methanols and tetraarylmethanes. Organic Chemistry Frontiers, 2022,9:3854.(一区，IF=5.281）[7-2022.pdf]6.Xia Zhao#,*, Li Xiong#, Lingyu She, Liwei Li, Ping Huang, Guang Liang*. The role and therapeutic implication of Protein tyrosine phosphatases in Alzheimer's disease. Biomed Pharmacother. 2022,151:113188. (二区，IF=7.42）[6-2022.pdf] 5.Xue Han，Jiajia Zhang，Li Zhou，Jiajia Wei，YuTu，Qiaojuan Shi，Yi Zhang，Juan Ren，Yi Wang，Huazhong Ying*，Guang Liang*. Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway. Phytother Res. 2022,36(6):2511-2523. (二区，IF=5.878） [5-2022.pdf]   4.Wu Luo, Lin Ye, Xueting Hu, Meihong Wang, Minxiu Wang, Leiming Jin, Zhongxiang Xiao, Jianchang Qian, Yi Wang, Wei Zuo, Lijiang Huang, Guang Liang*. MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non‐alcoholic fatty liver disease. Clin Transl Med. 2022,12(3):e777. (一区，IF=11.49）[4-2022.pdf]2021年3.Yawen Zhang, Linglan Tu，Yi Zhang, Jiehao Pan, Gaoli Zheng*, Lina Yin*. Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis. Drug Deliv. 2021,28(1):2534-2547. (二区，IF=6.419）[3-2021.pdf] 2.Jie Li, Jiaqi Yao, Lingfeng Chen, Dong Zou, Patrick J. Walsh*, Guang Liang*. Chemoselective acylation of N-acylglutarimides with N-acylpyrroles and aryl esters under transition-metal-free conditions. Organic Chemistry Frontiers, 2021,8:6344–6349. (一区，IF=5.3）[2-2021.pdf]1.Lingfeng Chen*, Yanmei Zhang, Lina Yin, Binhao Cai, Ping Huang, Xiaokun Li, Guang Liang*. Fibroblast growth factor receptor fusions in cancer: opportunities and challenges. J Exp Clin Cancer Res. 2021,40(1):345. (一区，IF=11.16）[1-2021.pdf]

2021 项目来源 项目名称 浙江省重点研发计划 肺炎及其并发症的药物开发研究-靶向MyD88防治肺炎及其并发症的新药发现研究 国家自然科学基金 靶向MyD88的PROTACs的发现及其在急性肺损伤中的作用研究 浙江省自然科学基金 苯并[d]噻唑类髓样分化因子88的降解剂的设计、合成及在感染性脓毒症中的治疗作用 浙江省自然科学基金 癌蛋白BORIS介导结直肠癌耐药机制及其靶向药物研究 浙江省自然科学基金 Man-RSMVT双靶向nano-in-micro递药系统治疗溃疡性结肠炎的作用和机制研究